In the wake of that latest flash exploit we looked into the Malwarebytes Anti-Exploit program. Malwarebytes protects agains Java exploits and can be overly aggressive with the Istaria launcher. At the current time, the only way around this issue is to disable Malwarebytes Anti-Exploit.
We've reached out to Malwarebytes about this but haven't heard back yet.
Microsoft's Enhanced Mitigation Experience Toolkit has been tested, which provides similar protection and it does not cause any issues.